This process cooperates with autophagy in a catabolic cascade that mediates entry into quiescence and is required to survive nutrient limitation (Mueller et al., eLife 2015).
Now we aim to characterize how cellular homeostasis and signaling networks regulate the ubiquitin dependent degradation of nutrient transporters. Therefore we will combine yeast genetics with quantitative proteomics and imaging approaches. Our results will help to understand how cells adjust their nutrient transporter repertoire on the cell surface in response to nutrient availability and thus have important general biological implications for the regulation of cellular growth.
Applicants should be highly motivated, with a strong background in cell- and molecular biology and/or biochemistry.
Please send your application (CV and two contacts for reference) per email to David Teis (firstname.lastname@example.org).
1. Huber, L.A., and Teis, D. (2016). Lysosomal signaling in control of degradation pathways. Curr Opin Cell Biol 39, 8-14.
2. Muller, M.*, Schmidt, O.*, Angelova, M., Faserl, K., Weys, S., Kremser, L., Pfaffenwimmer, T., Dalik, T., Kraft, C., Trajanoski, Z., Lindner H.H. and Teis, D. (2015). The coordinated action of the MVB pathway and autophagy ensures cell survival during starvation. eLife 4.
3. Adell, M.A.*, Vogel, G.F.*, Pakdel, M., Muller, M., Lindner, H., Hess, M.W., and Teis, D. (2014). Coordinated binding of Vps4 to ESCRT-III drives membrane neck constriction during MVB vesicle formation. J Cell Biol 205, 33-49.