Position for a master thesis in Immunology (Derudder group) at the Institute for Biomedical Aging Research
Possible starting date: February 2019
Objective: Dissecting the role of the miR-150 – c-Myb axis in B cells.
B cells are a prominent component of the immune system, especially due to their ability to produce antibodies upon stimulation. The development and function of these cells are controlled by a variety of genetic programs. Effectors of these programs are regulated by transcription factors and small non coding RNAs, like miRNAs, that dampen protein production. In this context, miR-150 has been reported to modulate B cell development and its effect has been suggested to stem from the repression of the transcription factor c-Myb. Yet, there is no evidence for such a direct regulation in B cells. In addition, a role for a miR-150 – c-Myb axis in B cell function, i.e. responses to stimulation, remains to be clarified.
Using genetic models, the master student will be investigating the effects of disrupting c-Myb – miR-150 association on primary progenitor as well as mature B cell responses to stimulation. In addition, the consequences of the genetic alterations on c-Myb expression will also be analyzed at the molecular level.
For more information, contact: Emmanuel.Derudder@uibk.ac.at